Clinical And Laboratory Assessment Of The Functional State Of Kidneys In Leukemia Patients
Keywords:
Hemoblastoses, leukemia, kidney dysfunctionAbstract
The literature review presents modern data on kidney damage in leukemia patients and the characteristics of their clinical and laboratory diagnostics. The main pathogenetic mechanisms for the development of renal dysfunction in hemoblastoses, including leukemic infiltration of renal tissue, tumor lysis syndrome, toxic effects of antitumor therapy, infectiousinflammatory complications, and systemic hemodynamic disorders, have been examined. Issues regarding the prevalence of acute kidney damage and chronic kidney disease in leukemia patients, as well as factors influencing the risk and severity of nephropathy, are highlighted. Particular attention is paid to modern methods for laboratory assessment of kidney function. The diagnostic significance of traditional indicators— creatinine, urea, glomerular filtration rate, general urine and electrolyte analysis—as well as promising biomarkers of early kidney damage, such as NGAL, KIM-1, and cystatin C, was analyzed. It has been shown that the use of modern biomarkers contributes to the earlier detection of renal dysfunction and allows for the timely adjustment of treatment tactics. It is emphasized that a comprehensive clinical and laboratory assessment of kidney condition is important for reducing complications, increasing treatment efficacy, and improving the prognosis in leukemia patients
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