Global Insights in Biomedical & Multidisciplinary Research
Global Insights in Biomedical & Multidisciplinary Research (GIBMR) is a peer-reviewed, open access journal focused on advancing interdisciplinary biomedical science through laboratory innovation, biotechnology, and integrative research approaches. The journal provides a platform for researchers working at the intersection of life sciences, engineering, computational research, and medicine. By encouraging cross-disciplinary collaboration, the journal aims to support scientific discoveries that contribute to healthcare advancement and biomedical innovation. Aim Global Insights in Biomedical & Multidisciplinary Research (GIBMR) aims to promote rigorous laboratory and interdisciplinary research that integrates biomedical sciences with technological and analytical advancements. The journal seeks to encourage collaboration across scientific disciplines and provide a global platform for the dissemination of innovative research that contributes to biomedical knowledge, healthcare improvement, and scientific development. Scope The journal publishes original research articles, review articles, systematic reviews, meta-analyses, and technical reports in a broad range of interdisciplinary biomedical fields. Areas of interest include, but are not limited to: Molecular Biology and Genetics Biotechnology and Bioengineering Immunology and Microbiology Biomedical Engineering and Medical Devices Computational Biology and Bioinformatics Artificial Intelligence in Healthcare Research Experimental and Laboratory Medicine Tissue Engineering and Regenerative Sciences Nanomedicine and Biomaterials Interdisciplinary Health Sciences Research The journal particularly welcomes studies that integrate biological sciences with engineering, computational approaches, and emerging technologies to advance biomedical research and healthcare innovation. Country of Publication: Germany City: Munich Medium of publication: Online Language(s) of publication: English Frequency of publication: Monthly (12 Issues per year) ISSN (Online): 3054-5900 ResearchBib: 9.755 Name of Publisher: Mr. Finn Müller (Individual Publisher) Address: Parkstadt Schwabing Marcel-Breuer-Strasse 15, Munich, 80807, Germany This journal is edited and published by Mr. Finn Müller at Munich, Germany
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The Role Of Preventive Healthcare In Reducing NonCommunicable Diseases Among Urban Population
Non-communicable diseases (NCDs) represent one of the leading public health problems worldwide and are responsible for significant mortality, disability, and economic burden. Urban populations are particularly vulnerable to chronic diseases due to sedentary lifestyles, unhealthy nutrition, environmental pollution, stress, and reduced physical activity. Preventive healthcare plays an essential role in reducing the prevalence and complications of noncommunicable diseases through early detection, health education, and lifestyle modification. The present study investigates the role of preventive healthcare in reducing non-communicable diseases among urban populations. Particular attention was devoted to health promotion strategies, preventive screening programs, vaccination coverage, public awareness campaigns, and lifestyle-related risk factors influencing population health. The obtained results demonstrated that preventive healthcare measures significantly contribute to reduction of cardiovascular diseases, diabetes, obesity, hypertension, and other chronic conditions. Early diagnosis, regular medical examinations, and community-based preventive interventions improve disease control and reduce healthcare burden
Copyright (c) 2026 https://creativecommons.org/licenses/by/4.0
Digital Health Technologies And Their Impact On Public Healthcare Management
Digital health technologies have become an essential component of modern public healthcare systems due to rapid technological progress and increasing demand for efficient healthcare management. The integration of digital solutions into healthcare practice significantly improves accessibility of medical services, accelerates information exchange, enhances patient monitoring, and supports evidence-based healthcare decision-making. The present study investigates the impact of digital health technologies on public healthcare management and evaluates their role in improving healthcare accessibility, quality of medical services, and organizational efficiency. Particular attention was devoted to electronic health records, telemedicine systems, mobile health applications, digital patient monitoring, and healthcare information technologies. The obtained results demonstrated that digital health technologies contribute to optimization of healthcare management processes, reduction of administrative workload, improvement of communication between healthcare providers and patients, and enhancement of preventive healthcare services. Telemedicine and digital monitoring systems significantly improved continuity of healthcare delivery and expanded access to medical consultation in remote areas. The study confirms that digital healthcare technologies represent an important direction in modernization of public health systems and possess substantial potential for improving healthcare efficiency, disease prevention, and long-term healthcare sustainability
Genetic Aspects Of Otosclerosis: Current Data On Predisposition, Candidate Genes, And Clinical Significance
This article presents an analytical review of current evidence on the genetic aspects of otosclerosis. Otosclerosis is considered a disorder of pathological bone remodeling of the otic capsule that most commonly causes stapes fixation and conductive or mixed hearing loss. The reviewed literature indicates that the disease is characterized by familial aggregation, autosomal-dominant inheritance with incomplete penetrance in a subset of families, and a pronounced polygenic and multifactorial background. The beststudied genetic signals involve RELN, TGFB1, BMP2, BMP4, MEPE, ACAN, SERPINF1, and FOXL1. However, several associations have not been consistently replicated across populations, highlighting substantial genetic heterogeneity. It is concluded that genetic markers cannot yet replace clinical diagnosis, but they are valuable for risk stratification in familial cases, early-onset disease, and bilateral involvement, and they provide a scientific basis for future personalized approaches
Molecular genetic markers in predicting the clinical course of cervical cancer according to data from the Samarkand regional branch of the Republican Specialized Scientific and Practical Medical Center of Oncology and Radiology
Cervical cancer (CC) remains a global health problem, particularly in developing countries. According to GLOBOCAN 2022, 604,000 new cases and 342,000 deaths from CC were recorded worldwide in 2020. In the structure of oncological morbidity and mortality in women worldwide, cervical cancer ranks fourth, and in developing countries this type of oncological pathology ranks first, while in economically developed countries it ranks third after uterine and ovarian cancer.
Predicting the Course of Pregnancy in Women with Diabetes Mellitus After COVID-19 Using Continuous Glucose Monitoring (CGM) Systems and Digital Remote Monitoring Devices
Diabetes mellitus is a significant risk factor for complicated pregnancy. COVID-19 infection can exacerbate metabolic and vascular disorders, increasing the likelihood of adverse perinatal outcomes. In recent years, continuous glucose monitoring (CGM) systems and digital remote monitoring devices have been actively implemented to continuously monitor the physiological parameters of pregnant women
Morphological Basis Of Mammary Gland Differentiation In Rat Offspring Under Conditions Of Impaired Thyroid Functional Activity
The thyroid gland plays a crucial role in regulation of metabolic, endocrine, and developmental processes within the mammalian organism. Thyroid hormones significantly influence tissue differentiation, cellular proliferation, hormonal balance, and morphofunctional maturation of reproductive organs, including mammary glands. Disturbances in thyroid functional activity during early ontogenesis may lead to structural and developmental abnormalities in hormonally dependent tissues. The present study investigates morphological features of mammary gland differentiation in rat offspring under conditions of impaired thyroid gland functional activity. Particular attention was devoted to histological organization, epithelial differentiation, stromal development, and morphometric characteristics of mammary gland structures under hypothyroid conditions. The obtained results demonstrated that thyroid dysfunction significantly affects structural maturation and differentiation processes of mammary gland tissues. Histological analysis revealed delayed epithelial development, reduced alveolar formation, stromal disorganization, vascular alterations, and decreased proliferative activity in experimental animals with impaired thyroid function
The Impact Of Academic Stress On Emotional Burnout Among Medical University Students
Academic stress has become one of the most significant psychological problems among medical university students due to intensive educational demands, high academic workload, emotional pressure, and continuous professional responsibility. Prolonged exposure to academic stress may negatively affect students’ emotional well-being and contribute to the development of emotional burnout syndrome. The present study investigates the relationship between academic stress and emotional burnout among medical university students. Particular attention was devoted to the influence of academic overload, examination anxiety, sleep disturbances, and psychological fatigue on emotional exhaustion and academic motivation.
Physical Health: How Our Character Traits Affect Our Body
This article looks at how our temperament affects our health and how it can lead to certain health problems. We are looking at this from an psychological point of view. The study looks at the ideas of I.P. Pavlov and Meyer Friedman. How they relate to heart disease, stomach problems and issues with our immune system. We found that people with a temperament are more likely to have heart problems while those with a melancholic temperament are more likely to have problems with their immune system. The goal of this article is to help us understand how our temperament can affect our health and how we can prevent health problems
Gut Microbiota Alterations In Patients With Chronic Heart Failure And Chronic Kidney Disease
Chronic heart failure (CHF) and chronic kidney disease (CKD) are closely interconnected pathological conditions associated with high morbidity and mortality worldwide. Recent studies suggest that intestinal microbiota plays an important role in the progression of both cardiovascular and renal dysfunction through inflammatory, metabolic, and immune-mediated mechanisms. The aim of the present study was to investigate alterations of gut microbiota in patients with chronic heart failure and chronic kidney disease and to evaluate their association with clinical and metabolic disturbances
Airborne Droplet Infections: Whooping Cough (Pertussis) Pathogenesis
This article examines the pathogenesis of pertussis, which belongs to the group of airborne (droplet-transmitted) infectious diseases. The etiological agent of the disease, Bordetella pertussis, its biological characteristics, mechanisms of transmission, and routes of entry into the human body are described. In addition, the processes of pathogen adhesion to the respiratory epithelium, its proliferation, and its harmful effects on the body through toxin production are outlined
Airborne Infections, Whooping Cough, Bordetella Pertussis, Respiratory Tract Infections
Study of the Clinical Course of Myopathosis in Horses and the Effectiveness of Treatment
This scientific work studied the clinical course of myopathy in horses, pathological changes in the muscular system, and the effectiveness of treatment. The aim of the study was to determine clinical signs in horses affected with myopathy, evaluate functional disorders of the locomotor apparatus, and analyze the effectiveness of комплекс treatment methods. During the study, decreased muscle tone, muscle pain, impaired coordination of movement, lameness, swelling, and a tendency to muscle atrophy were observed. Increased body temperature, pulse, and respiratory rate were also recorded in diseased horses. As a result of treatment, clinical signs in the experimental group decreased significantly, and the functional condition of the muscles recovered in a shorter period. The obtained results indicate the importance of early diagnosis and complex treatment in reducing the severity of myopathy in horses.
Management of Obesity and Metabolic DysfunctionAssociated Steatohepatitis (MASH) in Multimorbid Patients
Metabolic dysfunction-associated steatohepatitis (MASH), formerly known as non-alcoholic steatohepatitis (NASH), represents the progressive inflammatory phenotype of metabolic dysfunction-associated steatotic liver disease (MASLD). The recent nomenclature shift from NAFLD/NASH to MASLD/MASH reflects a fundamental reconceptualization of this condition not merely as a hepatic disorder, but as a systemic manifestation of metabolic dysregulation
Metabolic dysfunction-associated steatohepatitis
Pseudoexfoliation Syndrome As A Risk Factor For The Development Of Glaucoma
Pseudoexfoliation syndrome (PEX) is an age-related systemic disorder characterized by the accumulation of abnormal fibrillar extracellular material in ocular tissues and various organs of the body. In ophthalmology, pseudoexfoliation syndrome is considered one of the major risk factors for the development and progression of secondary open-angle glaucoma. Structural alterations associated with PEX contribute to impaired aqueous humor outflow, increased intraocular pressure, and progressive optic nerve damage
Improvement Of Accounting And Analysis Of Personnel Settlements For Labor Remuneration
This article examines the issues of improving the system of accounting and analysis of settlements with personnel for labor remuneration. The research analyzes the current procedure for accounting for wages, identifies existing problems, and proposes solutions for their elimination. The paper provides scientific recommendations for improving the efficiency of accounting processes through digitalization, ensuring the accuracy of payroll deductions, and correctly forming social contributions. Furthermore, it outlines prospects for developing methods to analyze the utilization of labor resources, which plays a crucial role in maintaining the financial stability and competitiveness of an enterprise in a market economy
Organization Of Labor Remuneration Accounting And Audit
The article examines the theoretical and practical aspects of organizing labor remuneration accounting and its subsequent audit in modern enterprises. The primary focus is placed on the methodology of calculating wages, bonuses, and social insurance deductions in accordance with the current regulatory framework. Furthermore, the study outlines the essential stages of the payroll audit process, including the verification of primary documents, compliance with labor laws, and the assessment of internal control systems. The author suggests improvements for enhancing the accuracy of payroll records and minimizing financial risks related to personnel costs
Cardiovascular Complications Of A(H1n1) Influenza Infection And Pathogenetic Mechanisms Of Its Effects On The Myocardium And Vascular System
This article analyzes the impact of the influenza virus on the cardiovascular system and its role in the development of acute cardiovascular complications. The infection induces systemic inflammation, endothelial dysfunction, and prothrombotic changes, thereby increasing the risk of acute coronary syndrome, myocarditis, cardiac rhythm disturbances, and decompensation of chronic heart failure. During seasonal influenza epidemics, timely prevention and cardiovascular risk stratification are considered key measures for reducing mortality and the frequency of severe complications
Clinical And Laboratory Assessment Of The Functional State Of Kidneys In Leukemia Patients
The literature review presents modern data on kidney damage in leukemia patients and the characteristics of their clinical and laboratory diagnostics. The main pathogenetic mechanisms for the development of renal dysfunction in hemoblastoses, including leukemic infiltration of renal tissue, tumor lysis syndrome, toxic effects of antitumor therapy, infectiousinflammatory complications, and systemic hemodynamic disorders, have been examined. Issues regarding the prevalence of acute kidney damage and chronic kidney disease in leukemia patients, as well as factors influencing the risk and severity of nephropathy, are highlighted. Particular attention is paid to modern methods for laboratory assessment of kidney function. The diagnostic significance of traditional indicators— creatinine, urea, glomerular filtration rate, general urine and electrolyte analysis—as well as promising biomarkers of early kidney damage, such as NGAL, KIM-1, and cystatin C, was analyzed. It has been shown that the use of modern biomarkers contributes to the earlier detection of renal dysfunction and allows for the timely adjustment of treatment tactics. It is emphasized that a comprehensive clinical and laboratory assessment of kidney condition is important for reducing complications, increasing treatment efficacy, and improving the prognosis in leukemia patients
Methods Of Teaching Elements of Geometry in The 4 th Grade
This article analyzes effective methods, stages and didactic opportunities for teaching elements of geometry in mathematics in the 4th grade. The study covers teaching methods aimed at developing spatial imagination, logical thinking, observation and measurement skills in students. Also, modern approaches to organizing practical classes on recognizing geometric shapes, determining their properties, drawing and measuring have been developed. The article scientifically substantiates the active involvement of students in the lesson process, the development of independent thinking and analytical skills through the use of interactive methods, game activities and information technologies
Methodology Of Developing The Intellectuality Of Primary Students Through Didactic Games
This article analyzes the role and importance of didactic games in developing the intellectual potential of primary school students. The article covers the functions of didactic games in the educational process, their types and their role in teaching methods. Also, methodological approaches have been developed using the example of a system of game tasks aimed at forming students' thinking, attention, memory, and logical analysis skills. According to the results of the study, lessons organized on the basis of game activities increase students' interest in learning, develop independent thinking, problem-solving skills, and creative thinking
Surgical Aspects Of Choice Of Tactics For Treatment Of Complications Of Diabetic Foot Syndrome
Currently, research is ongoing in the world to improve the results of surgical treatment of patients with gangrene of the lower extremities against the background of diabetes mellitus, which is associated with the steady growth of this population of patients, ambiguity of approaches in surgical tactics and unsatisfactory treatment results. The need to further investigate the clinical aspects of this pathology is undeniable, and the emergence of modern diagnostic methods, new enduscular minimally invasive technologies and a modern idea of the pathogenesis of the development of critical ischemia allow us to study the problem of treating complicated forms of diabetic foot syndrome from a new perspective of surgery. Based on the above, the problem of choosing therapeutic and diagnostic tactics, the stage of surgical interventions and the prevention of complications in patients with diabetic gangrene of the lower extremities is extremely relevant both from a scientific and practical point of view
Diagnosis Of Breast Cancer: Clinical-Statistical Analysis And The Role Of The Bi-Rads System In Differentiating Benign And Malignant Lesions
Breast cancer is the leading oncological disease among women worldwide, which underscores the critical importance of improving early diagnostic methods. This study presents a retrospective clinical-statistical analysis of mammographic data from 30 patients with breast lesions, assessing the diagnostic value of the BI-RADS classification system. Malignancy was verified in 19 patients (63.3%) and benign lesions in 11 (36.7%). All malignant cases corresponded to BI-RADS categories 4–5, and all benign cases to categories 2–3. The mean age in the malignant group (52.2±7.1 years) was significantly higher than in the benign group (33.3±4.3 years; t=7.999; p
This article provides a scientific and theoretical analysis of antigens and antibodies as the main components of the immune system. The chemical structure of antigens, their role in triggering the immune response, as well as the types of antibodies, their biological functions, and their role in the body's defense mechanisms are comprehensively described. In addition, the clinical significance of antigen–antibody reactions, their application in diagnostic and therapeutic fields, and their use in modern biotechnologies are analyzed. Through this article, the complex mechanisms of immunological processes are explained in depth.
Psychological Features Of Socio-Psychological Adaptation Of International Students In A Medical University Of Uzbekistan
The article examines the problem of socio-psychological adaptation of international students from India studying at a medical university in Uzbekistan. The results of the study show that most second-year students generally adapt successfully to the social conditions of a foreign country, which is manifested in a satisfactory level of social inclusion, acceptance of others, the formation of interpersonal relationships, and a moderately positive emotional background
Cybersecurity Awareness Among Healthcare Workers: A Critical Imperative for Patient Safety in the Digital Age
The rapid digitization of healthcare has fundamentally transformed patient care delivery, enabling seamless data sharing, real-time monitoring, and improved operational efficiency through electronic health records (EHRs) and Internet of Medical Things (IoMT) devices. However, this digital revolution has simultaneously exposed healthcare organizations to unprecedented cybersecurity threats, making the human element—particularly healthcare workers—the most critical yet vulnerable component of the security ecosystem
Biomarkers: The Role of Medicinal Chemistry in Early Detection of Diseases
Biomarkers are biological indicators that allow objective assessment of physiological and pathological processes in the body or response to treatment. This article reviews the types of biomarkers, the role of medicinal chemistry in their detection, their importance in diagnosis and prognosis, and the main biomarkers used in oncology based on a scientific approach. It also covers advanced analytical methods and their application in clinical practice. identification
Measures To Provide The Population With Safe Food Products In Situations Of Toxic Substance Spread Among The Population
This article provides a detailed discussion of the urgent issues related to ensuring the population is supplied with clean and safe food products in emergency situations involving the spread of toxic substances. It analyzes the sources of poisoning agents, their pathways of spread, and their negative impact on food products. It also substantiates the necessity of taking prompt and effective measures to protect public health under such conditions. The article pays special attention to the formation of safe food reserves, their proper storage, processing, and the organization of distribution systems to the population. In addition, it highlights important aspects such as strict adherence to sanitary and hygienic standards, laboratory control of food quality, and the avoidance of consuming food obtained from contaminated areas. Furthermore, the importance of strengthening cooperation among government agencies, medical institutions, and other responsible services in emergency situations is emphasized, along with the timely and reliable provision of information to the population, as well as conducting awareness and educational activities. This article aims to develop practical recommendations for protecting the population in conditions of toxic substance contamination and ensuring their continuous supply of high-quality and safe food products.
Morphological Changes in the Pancreas of Rats with Experimental Diabetes Chronically Exposed to Pesticides Over a 9-Month Period
The present study aims to investigate the dynamic morphological changes occurring in the pancreas of rats with experimentally induced diabetes mellitus under the influence of chronic pesticide exposure over different time periods, particularly within 6 months. During the initial 3-month period, the pancreas of rats with diabetes mellitus exposed to pesticides was examined after decapitation. The pancreatic response to pesticide exposure in diabetic conditions over a 3- month period was primarily manifested as acute injury. Morphologically, the pancreatic capsule appeared relatively thickened, the surface was irregular, and signs of vascular congestion were observed.
Ubaydullayev Abbosxoʻja Xikmatilla oʻgʻli
The Impact of Assessment Systems on Children’s Psychology
Assessment systems play a pivotal role in modern education, directly influencing children’s academic progress and psychological development. While these systems are designed to measure learning outcomes and provide feedback, they also shape children's motivation, self-esteem, stress levels, and overall mental well-being. This paper explores the impact of various assessment methods, including formative, summative, standardized, and performance-based assessments, on children’s psychology. By reviewing current literature and case studies from multiple countries, this study highlights both the positive and negative consequences of assessment practices. Findings indicate that excessive reliance on high-stakes testing may increase anxiety and reduce intrinsic motivation, whereas continuous and constructive assessment can enhance confidence and learning engagement. Recommendations are provided for policymakers, educators, and psychologists to design assessment systems that support holistic child development.
Methods and tools used to evaluate students
Biophysical Mechanisms Of Ion Transport Across Cell Membranes
Ion transport across cell membranes is a fundamental biophysical process essential for maintaining cellular homeostasis, electrical activity, and signal transmission. The movement of ions such as sodium (Na⁺), potassium (K⁺), calcium (Ca²⁺), and chloride (Cl⁻) is regulated by complex mechanisms involving passive and active transport systems. Understanding these processes is critical for explaining physiological functions and pathological conditions. This study aims to analyze the biophysical mechanisms underlying ion transport across cell membranes. The research is based on theoretical analysis and interpretation of experimental data related to membrane permeability, ion channels, and transport proteins. Both passive mechanisms, including diffusion and facilitated diffusion, and active mechanisms such as ion pumps and ATP-dependent transport are considered. The results indicate that ion transport is governed by electrochemical gradients, membrane potential, and selective permeability of ion channels. Active transport systems, particularly the sodium-potassium pump, play a key role in maintaining ionic balance and cellular function. Disruption of these mechanisms may lead to significant physiological disorders.
Morphological And Morphometric Changes Of The Pancreas In Acute Choledocholithiasis
Acute choledocholithiasis is a pathological condition characterized by obstruction of the common bile duct, leading to significant disturbances in biliary outflow and secondary involvement of adjacent organs, particularly the pancreas. Due to the close anatomical and functional relationship between the biliary tract and the pancreatic ductal system, acute obstruction may induce inflammatory and structural changes in pancreatic tissue. The present study aims to evaluate the morphological and morphometric alterations of the pancreas in patients with acute choledocholithiasis.