Airborne Droplet Infections: Whooping Cough (Pertussis) Pathogenesis
Keywords:
Airborne Infections, Whooping Cough, Bordetella Pertussis, Respiratory Tract InfectionsAbstract
This article examines the pathogenesis of pertussis, which belongs to the group of airborne (droplet-transmitted) infectious diseases. The etiological agent of the disease, Bordetella pertussis, its biological characteristics, mechanisms of transmission, and routes of entry into the human body are described. In addition, the processes of pathogen adhesion to the respiratory epithelium, its proliferation, and its harmful effects on the body through toxin production are outlined
References
1. Abdiraxmonova, O.J. Airborne droplet infections. Course of whooping cough and epidemic parotitis in children. Best Intellectual Studies, 47(2), (2025-06-20), pp. 185–189.
2. Al-Mahmoud, S., & Ahmed, Z. Molecular Typing of Bordetella pertussis Strains in Central Asia. Journal of Infection and Public Health, 15(7), (2022), pp. 909–916.
3. Althouse, B. M., & Scarpino, S. V. Epidemiological Consequences of an Ineffective Bordetella pertussis Vaccine. (2014), pp. 705–714.
4. Bettiol, S., Wang, K., Thompson, M.J., et al. Symptomatic Treatment of Cough in Whooping Cough. Cochrane Database of Systematic Reviews, 5: CD003257 (2012), pp. 456–461.
5. Bordetella pertussis – Wikipedia article. Encyclopedia entry. (2026), pp. 386–393.
6. Centers for Disease Control and Prevention (CDC). Clinical Overview of Pertussis (Whooping Cough). Atlanta: CDC (2025), pp. 653–662.
7. Cherry, J.D., & Heininger, U. Pertussis and Parapertussis: Epidemiology and Immunization Strategies. Clinical Infectious Diseases, 68(3), (2019), pp. 341–348.
8. Crawford, S., & Johnson, L.P. The Role of Vaccination in Preventing Pertussis. Vaccine, 36(41), (2018), pp. 6119–6125.
9. Esposito, S., & Principi, N. Re-Emerging Pertussis: The Role of Parapertussis. International Journal of Pediatrics, 18(4), (2023), pp. 112–118.
10. Fauci, A.S., & Braunwald, E. Harrison’s Principles of Internal Medicine. McGraw-Hill (2018), pp. 114–119.
11. Goodwin, J., & Novak, M. The Role of Parapertussis in the Epidemiology of Bordetella Infections. Emerging Infectious Diseases, 27(5), (2021), pp. 956–964.
12. Whooping cough and parapertussis pathogens. Journal of Science-Innovative Research in Uzbekistan, 3(7), (2025), pp. 523–527.
13. Liko, J., Robinson, G., et al. Priming with Whole-Cell Versus Acellular Pertussis Vaccine. New England Journal of Medicine, 368(7), (2013), pp. 581–582.
14. Mattoo, S., & Cherry, J.D. Molecular Pathogenesis of Bordetella pertussis Infections. Clinical Microbiology Reviews, 34(2), (2021), pp. 185–195.
15. Ministry of Health of the Republic of Uzbekistan. Epidemiological situation of whooping cough and parapertussis. Tashkent: MoH (2023), pp. 561–563.
16. Paddock, C.D., Sanden, G.N., Cherry, J.D., et al. Pathology and Pathogenesis of Fatal Bordetella pertussis Infection in Infants. Clinical Infectious Diseases, 47(3), (2008), pp. 328–338.
17. Pramono, R.X., Imtiaz, S.A., Rodriguez-Villegas, E. A Cough-Based Algorithm for Automatic Diagnosis of Pertussis. PLoS One, 11(9): e0162128 (2016), pp. 115–117.
18. Qin, X., Zhang, J., & Chen, M. Antibiotic Resistance in Bordetella Species: A Global Perspective. Journal of Antimicrobial Chemotherapy, 75(8), (2020), pp. 2221–2230.
19. Smith, J. Public Health and Epidemiology. Springer (2020), pp. 906–909.
20. Tan, T., Dalby, T., Forsyth, K., Halperin, S.A., & Plotkin, S. Pertussis Vaccination Strategies and Impact on Disease Control. The Lancet Infectious Diseases, 19(2), (2019), pp. 186–192.
21. UNICEF. Information about whooping cough. UNICEF Uzbekistan (2025), pp. 119–122.
22. Wang, X., & Jones, R.L. Pertussis in Adolescents and Adults: Current Perspectives. Journal of Infection and Public Health, 13(6), (2020), pp. 979–986.
23. World Health Organization (WHO). Pertussis Surveillance and Immunization Coverage. Geneva: WHO Press (2022), pp. 771–774.
24. World Health Organization (WHO). Pertussis vaccines: WHO position paper. Weekly Epidemiological Record (2023), pp. 116–119.
25. Yuldashev, A.Y. Basics of Medicine. Tashkent: Uzbekistan (2018), pp. 181–183.
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