Global Insights in Biomedical & Multidisciplinary Research
Global Insights in Biomedical & Multidisciplinary Research (GIBMR) is a peer-reviewed, open access journal focused on advancing interdisciplinary biomedical science through laboratory innovation, biotechnology, and integrative research approaches. The journal provides a platform for researchers working at the intersection of life sciences, engineering, computational research, and medicine. By encouraging cross-disciplinary collaboration, the journal aims to support scientific discoveries that contribute to healthcare advancement and biomedical innovation. Aim Global Insights in Biomedical & Multidisciplinary Research (GIBMR) aims to promote rigorous laboratory and interdisciplinary research that integrates biomedical sciences with technological and analytical advancements. The journal seeks to encourage collaboration across scientific disciplines and provide a global platform for the dissemination of innovative research that contributes to biomedical knowledge, healthcare improvement, and scientific development. Scope The journal publishes original research articles, review articles, systematic reviews, meta-analyses, and technical reports in a broad range of interdisciplinary biomedical fields. Areas of interest include, but are not limited to: Molecular Biology and Genetics Biotechnology and Bioengineering Immunology and Microbiology Biomedical Engineering and Medical Devices Computational Biology and Bioinformatics Artificial Intelligence in Healthcare Research Experimental and Laboratory Medicine Tissue Engineering and Regenerative Sciences Nanomedicine and Biomaterials Interdisciplinary Health Sciences Research The journal particularly welcomes studies that integrate biological sciences with engineering, computational approaches, and emerging technologies to advance biomedical research and healthcare innovation. Country of Publication: Germany City: Munich Medium of publication: Online Language(s) of publication: English Frequency of publication: Monthly (12 Issues per year) ISSN (Online): 3054-5900 ResearchBib: 9.755 Name of Publisher: Mr. Finn Müller (Individual Publisher) Address: Parkstadt Schwabing Marcel-Breuer-Strasse 15, Munich, 80807, Germany This journal is edited and published by Mr. Finn Müller at Munich, Germany
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Results Of Minimally Invasive Treatment Of Complex Inguinal Hernias
Minimally invasive surgery has a wide range in modern surgery. The stages of endovisual intervention technology are based on diagnostic laparoscopy, which serves as the surgeon's savior in many difficult situations. If at the end of the 20th century all abdominal herniology was based on manual surgery, now visual or remote robotic surgery is preferred. Endovisual surgery is one of the safest methods for combined surgical pathology of the abdominal organs.
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Oxidized LDL and macrophage activation in atherosclerosis: Molecular mechanisms, immunological plasticity, and novel therapeutic strategies
This analytical article is devoted to studying the central link in the pathogenesis of atherosclerosis — the molecular interaction between oxidized low-density lipoproteins (oxLDL) and macrophages. Atherosclerosis is not just a buildup of cholesterol, but a complex chronic immune-inflammatory process in the arterial wall. The paper analyzes the absorption of oxldl by scavenger-receptors (CD36, PAFR, LOX-1), polarization of macrophages to phenotypes M1 (pro-inflammatory) and M2 (anti-inflammatory), and signaling pathways (TLR4/NF-kB, eEF2K) that control these processes. The analysis provides scientific evidence for recent scientific discoveries over the past 10 years, particularly the mechanisms by which macrophages survive in stressful conditions and the anti-atherosclerotic effects of natural compounds such as Puerarin.The findings of the study will help identify new molecular targets for atherosclerosis therapy
Structure of the heart and blood vessels: Anatomical differences between arteries and veins
The cardiovascular system is one of the most important systems in the human body, delivering oxygen and nutrients to all cells of the body. This scientific article analyzes the anatomical structure, functional features, and differences between arteries and veins. The study examined the layers of the blood vessel walls, the level of elasticity, the effect of blood pressure, and the presence of valves. The results showed that arteries have thick, elastic walls that carry blood from the heart to the organs under high pressure, while veins have thinner walls and valves that help return blood to the heart. The study is important for understanding and preventing cardiovascular disease.
Artificial Intelligence: An Important Factor In The Development Of Modern Society
This article examines the role of artificial intelligence as one of the key factors in the development of modern society. The study analyzes the impact of artificial intelligence technologies on various fields, including education, economics, healthcare, industry, and information systems. The opportunities created by intelligent systems in increasing labor productivity, accelerating digital transformation, and improving the quality of life are highlighted. At the same time, the article discusses important issues related to the ethical, social, and security aspects of artificial intelligence. The research emphasizes that the effective and responsible use of artificial intelligence technologies serves as an important foundation for sustainable development and innovation in society.
Comparative Analysis Of Interrelationship Markers Of The Cytokin System In The Blood In Patients With Rheumatoid Arthritis And Related IR
Rheumatoid arthritis is a chronic autoimmune disease characterized by systemic inflammation and joint damage. In recent years, it has been found that a large proportion of patients with rheumatoid arthritis develop insulin resistance, suggesting that this condition is a combination of immune and metabolic disorders. Studies show a clear link between rheumatoid arthritis (RA) and insulin resistance (IR). Chronic inflammation in RA contributes to the development of carbohydrate metabolism disorders, making IR a common comorbid condition
Rheumatoid arthritis and related insulin resistance
Impаct of Rheumаtic Fever on the Cаrdiovаsculаr System: Modern Аpproаches to Diаgnosis аnd Treаtment
Rheumаtic fever is аn аutoimmune inflаmmаtory diseаse thаt develops following phаryngeаl infection cаused by Group А βhemolytic Streptococcus, with cаrdiovаsculаr involvement representing its most severe complicаtion. The pаthogenesis of the diseаse is primаrily bаsed on the mechаnism of moleculаr mimicry, whereby аntibodies аnd T lymphocytes generаted аgаinst streptococcаl аntigens cross-reаct with myocаrdiаl, endocаrdiаl, аnd vаlvulаr tissues, leаding to immune-mediаted cаrdiаc dаmаge. This аrticle аnаlyzes the mechаnisms through which rheumаtic fever аffects the cаrdiovаsculаr system, the stаges of rheumаtic cаrditis, morphologicаl аnd functionаl аlterаtions of the cаrdiаc vаlves, аnd the long-term hemodynаmic consequences of the diseаse. Furthermore, the diаgnostic vаlue of clinicаl -mаnifestаtions, lаborаtory investigаtions, аnd instrumentаl exаminаtions including echocаrdiogrаphy, electrocаrdiogrаphy, inflаmmаtory biomаrkers, аnd serologicаl mаrkers confirming streptococcаl infection - is comprehensively discussed. The аrticle аlso reviews contemporаry therаpeutic strаtegies, including аntibаcteriаl therаpy, аnti-inflаmmаtory treаtment, mаnаgement of heаrt fаilure, secondаry prophylаxis, аnd evidence-bаsed аpproаches for the prevention of rheumаtic heаrt diseаse in аccordаnce with current internаtionаl recommendаtions.
Peat -Based Rust Modifier In Protection Of Metal Surfaces Of Agricultural Equipment From Rust
This article presents the results of a scientific study on the use of a protective coating made of a peat-based rust modifier to protect metal surfaces from corrosion under the influence of an aggressive environment . Corrosion of metal surfaces of agricultural machinery under the influence of an aggressive environment is one of the current problems. Therefore, in order to implement a new method of its prevention and protection, this research was carried out and positive results were achieved. It was observed that the metal surfaces were improved several times compared to conventional methods of protection, and recommendations on the method and results of application are given.
Features Of The Mdr1 (C3435t) Polymorphism In Non-Syndromic Congenital Orofacial Clefts
The present study investigated the MDR1 (C3435T) polymorphism in patients with non-syndromic congenital orofacial clefts in Uzbekistan. Comparative analysis of allele and genotype frequencies demonstrated no statistically significant differences between affected patients and healthy controls. Based on the obtained findings, the MDR1 (C3435T) polymorphism cannot be considered an independent genetic marker associated with an increased risk of non-syndromic congenital orofacial clefts in the Uzbek population
Promotion And Development of Youth Consciousness and Culture
It was noted that the reforms being carried out in our country, the effective use of the methods of legal education are important in a responsible period of change. In the era of globalization, scientific and innovative development, it is necessary to adequately use the unique methods of raising the legal awareness and legal culture of the population, the best positive practices of advocacy
The Importance Of Play Activities In Preschool Educational Institutions
This article analyzes the role of play activities in the development of children within preschool educational institutions and their impact on cognitive, physical, speech, and social development from a scientific perspective. In addition, the pedagogical significance of different types of play and the role of educators in organizing play activities are discussed.
Digital Childhood And Emotional Development In Children: Contemporary Psycho-Pedagogical Challenges
This article presents a systematic literature review examining the relationship between children's engagement with digital technologies and their emotional development, with a focus on contemporary psycho-pedagogical challenges. Publications from 2010 to 2024 indexed in PubMed, Scopus, PsycINFO, and Web of Science were analysed. The review addresses theoretical frameworks for understanding digital childhood, empirical evidence on the effects of screen time, social media use, and digital game engagement on emotional regulation, empathy, anxiety, and social competence in children and adolescents, as well as protective factors and evidence-based pedagogical responses. The analysis reveals a nuanced picture: while excessive and unstructured digital technology use is associated with elevated emotional dysregulation, social anxiety, and reduced empathy, moderate and purposefully scaffolded digital engagement can support emotional learning and social connection
Diabetic Gangrene Of The Lower Limbs – Analysis Of Treatment Outcomes And Long-Term Survival
Diabetic ulcers are not only a common problem but also one of the serious and costly complications of diabetes. Significant risk factors for amputation in patients include male sex, a history of nicotine use, duration of foot ulcers, the presence of destructive changes in the foot, and excessive body weight. A history of ulcers increases the risk of developing another ulcer in diabetic patients. In 20–58% of patients, a new ulcer develops within one year after wound healing. Studies have shown that in patients with recurrent foot ulcers, the rate of amputations is ultimately 2.23 times higher than in patients with primary foot ulcers. To study long-term survival and treatment outcomes in patients with diabetic gangrene of the lower limbs (DGL) after limb amputation at various levels. The study is based on the analysis of treatment outcomes in 559 diabetic patients with complicated purulent-necrotic lesions of the foot (DGL) over the period from 2020 to 2023. During the follow-up of the control group, after 1 year, 89 patients remained under observation. Of these 89 patients, 60% retained weight-bearing function of the lower limb due to various operations performed at the level of the foot and toes
neuro-ischemic form of diabetic foot syndrome
Menopause: Hormonal Changes and Modern Treatment Approaches
The menopausal transition is a natural stage in a woman’s reproductive aging, accompanied by complex neuroendocrine changes and the development of clinical symptoms of varying severity. The relevance of this topic stems from the high prevalence of menopausal disorders, which significantly impact the quality of life, work capacity, and health status of middleaged women. The aim of this review is to analyze current data on hormonal changes occurring during the menopausal transition, as well as to evaluate the effectiveness of existing medical treatment methods. The review examines the characteristics of changes in the secretion of estrogens, folliclestimulating hormone, anti-Müllerian hormone, and inhibin B, as well as changes in the activity of the hypothalamic-pituitaryovarian axis and their role in the development of vasomotor, psychoemotional, and urogenital disorders. Modern approaches to the management of menopausal symptoms are presented, including menopausal hormone therapy, non-hormonal treatment methods, and lifestyle modifications. The analysis conducted indicates the need for a personalized approach to the management of women during the menopausal transition, taking into account clinical characteristics, risk factors, and the individual needs of patients.
Methods For Developing Algorithmic Thinking
This article analyzes the theoretical foundations of the concept of algorithmic thinking, its role in the modern educational system, and effective methods for its development. Algorithmic thinking is the ability to analyze a problem step-by-step, decompose it into logical parts, and develop a solution based on a precise sequence. In today’s digital society, this skill is of critical importance not only in programming or information technology but also in economics, engineering, natural sciences, and social spheres. The article substantiates the effectiveness of methods such as problem-based learning, project-based learning, solving logic puzzles, working with flowcharts, and utilizing programming environments in shaping algorithmic thinking. Furthermore, practical recommendations are provided to foster independent and systemic reasoning in students. Research results indicate that developing algorithmic thinking at an early stage enhances educational quality and strengthens digital competencies
Influence Of Harmful And Hazardous Factors Of The Production Environment On The Health Of Workers In The Production Of Metal Structures
Metal fabrication is one of those industries with high levels of exposure to adverse production factors. During their work, workers are exposed to a range of harmful and hazardous factors, including industrial noise, dust, metal aerosols, welding fumes, unfavorable microclimate, significant physical exertion, and the stress of the work process. Long-term exposure to these factors can lead to the development of occupational and work-related diseases, decreased productivity, and a deterioration in the quality of life of workers.
Free Radicals, Oxidative Stress And Antioxidant Systems
Free radicals and of oxygen reactive forms ( KRSh ) and nitrogen reactive forms ( ARS ) aerobic in organisms mitochondrial breath to take , enzymatic processes , immune system protection reactions and exogenous environmental stressors of the impact natural product as permanent accordingly harvest become The outer atom or molecular in orbitals one or one how many unpaired electrons existence with characterized this substances short biological half decay to the period and extreme high chemical to activity As a result , they cell vital important macromolecules , including lipids , proteins , carbohydrates and nuclein acids with dynamic accordingly mutual to the effect enters [1.2]. Physiological normative in concentrations free radicals cell signal transduction within genes expression , veins tone management and immune protection coordinator important homeostatic regulators task However , this prooxidants too much outside many working release , endogenous antioxidant systems shortage or end with together when it is over , it leads to oxidative stress take It comes . This is cancer , dermatitis , cataracts , stroke and asthma such as to diseases take comes
Analysis and Current Problems of Greening Small Cities in Arid Conditions
The article examines current problems of greening small cities located in arid climatic conditions. An analysis of green spaces in the cities of Khanabad, Yangiyo‘l, and Chinoz was carried out. The main factors contributing to the degradation of landscaping systems were identified, including high anthropogenic pressure, reduction of green areas, insufficient use of adapted tree and shrub species, violations of maintenance technologies, and lack of irrigation. Climatic, soil, and ecological characteristics of the territories affecting the sustainability of green plantings were investigated. Measures aimed at improving urban greening systems are proposed, including the reconstruction of existing plantings, expansion of plant diversity, development of vertical landscaping, and rational use of vacant urban areas.
The Role Of Preventive Healthcare In Reducing NonCommunicable Diseases Among Urban Population
Non-communicable diseases (NCDs) represent one of the leading public health problems worldwide and are responsible for significant mortality, disability, and economic burden. Urban populations are particularly vulnerable to chronic diseases due to sedentary lifestyles, unhealthy nutrition, environmental pollution, stress, and reduced physical activity. Preventive healthcare plays an essential role in reducing the prevalence and complications of noncommunicable diseases through early detection, health education, and lifestyle modification. The present study investigates the role of preventive healthcare in reducing non-communicable diseases among urban populations. Particular attention was devoted to health promotion strategies, preventive screening programs, vaccination coverage, public awareness campaigns, and lifestyle-related risk factors influencing population health. The obtained results demonstrated that preventive healthcare measures significantly contribute to reduction of cardiovascular diseases, diabetes, obesity, hypertension, and other chronic conditions. Early diagnosis, regular medical examinations, and community-based preventive interventions improve disease control and reduce healthcare burden
Digital Health Technologies And Their Impact On Public Healthcare Management
Digital health technologies have become an essential component of modern public healthcare systems due to rapid technological progress and increasing demand for efficient healthcare management. The integration of digital solutions into healthcare practice significantly improves accessibility of medical services, accelerates information exchange, enhances patient monitoring, and supports evidence-based healthcare decision-making. The present study investigates the impact of digital health technologies on public healthcare management and evaluates their role in improving healthcare accessibility, quality of medical services, and organizational efficiency. Particular attention was devoted to electronic health records, telemedicine systems, mobile health applications, digital patient monitoring, and healthcare information technologies. The obtained results demonstrated that digital health technologies contribute to optimization of healthcare management processes, reduction of administrative workload, improvement of communication between healthcare providers and patients, and enhancement of preventive healthcare services. Telemedicine and digital monitoring systems significantly improved continuity of healthcare delivery and expanded access to medical consultation in remote areas. The study confirms that digital healthcare technologies represent an important direction in modernization of public health systems and possess substantial potential for improving healthcare efficiency, disease prevention, and long-term healthcare sustainability
Genetic Aspects Of Otosclerosis: Current Data On Predisposition, Candidate Genes, And Clinical Significance
This article presents an analytical review of current evidence on the genetic aspects of otosclerosis. Otosclerosis is considered a disorder of pathological bone remodeling of the otic capsule that most commonly causes stapes fixation and conductive or mixed hearing loss. The reviewed literature indicates that the disease is characterized by familial aggregation, autosomal-dominant inheritance with incomplete penetrance in a subset of families, and a pronounced polygenic and multifactorial background. The beststudied genetic signals involve RELN, TGFB1, BMP2, BMP4, MEPE, ACAN, SERPINF1, and FOXL1. However, several associations have not been consistently replicated across populations, highlighting substantial genetic heterogeneity. It is concluded that genetic markers cannot yet replace clinical diagnosis, but they are valuable for risk stratification in familial cases, early-onset disease, and bilateral involvement, and they provide a scientific basis for future personalized approaches
Molecular genetic markers in predicting the clinical course of cervical cancer according to data from the Samarkand regional branch of the Republican Specialized Scientific and Practical Medical Center of Oncology and Radiology
Cervical cancer (CC) remains a global health problem, particularly in developing countries. According to GLOBOCAN 2022, 604,000 new cases and 342,000 deaths from CC were recorded worldwide in 2020. In the structure of oncological morbidity and mortality in women worldwide, cervical cancer ranks fourth, and in developing countries this type of oncological pathology ranks first, while in economically developed countries it ranks third after uterine and ovarian cancer.
Predicting the Course of Pregnancy in Women with Diabetes Mellitus After COVID-19 Using Continuous Glucose Monitoring (CGM) Systems and Digital Remote Monitoring Devices
Diabetes mellitus is a significant risk factor for complicated pregnancy. COVID-19 infection can exacerbate metabolic and vascular disorders, increasing the likelihood of adverse perinatal outcomes. In recent years, continuous glucose monitoring (CGM) systems and digital remote monitoring devices have been actively implemented to continuously monitor the physiological parameters of pregnant women
Morphological Basis Of Mammary Gland Differentiation In Rat Offspring Under Conditions Of Impaired Thyroid Functional Activity
The thyroid gland plays a crucial role in regulation of metabolic, endocrine, and developmental processes within the mammalian organism. Thyroid hormones significantly influence tissue differentiation, cellular proliferation, hormonal balance, and morphofunctional maturation of reproductive organs, including mammary glands. Disturbances in thyroid functional activity during early ontogenesis may lead to structural and developmental abnormalities in hormonally dependent tissues. The present study investigates morphological features of mammary gland differentiation in rat offspring under conditions of impaired thyroid gland functional activity. Particular attention was devoted to histological organization, epithelial differentiation, stromal development, and morphometric characteristics of mammary gland structures under hypothyroid conditions. The obtained results demonstrated that thyroid dysfunction significantly affects structural maturation and differentiation processes of mammary gland tissues. Histological analysis revealed delayed epithelial development, reduced alveolar formation, stromal disorganization, vascular alterations, and decreased proliferative activity in experimental animals with impaired thyroid function
The Impact Of Academic Stress On Emotional Burnout Among Medical University Students
Academic stress has become one of the most significant psychological problems among medical university students due to intensive educational demands, high academic workload, emotional pressure, and continuous professional responsibility. Prolonged exposure to academic stress may negatively affect students’ emotional well-being and contribute to the development of emotional burnout syndrome. The present study investigates the relationship between academic stress and emotional burnout among medical university students. Particular attention was devoted to the influence of academic overload, examination anxiety, sleep disturbances, and psychological fatigue on emotional exhaustion and academic motivation.
Physical Health: How Our Character Traits Affect Our Body
This article looks at how our temperament affects our health and how it can lead to certain health problems. We are looking at this from an psychological point of view. The study looks at the ideas of I.P. Pavlov and Meyer Friedman. How they relate to heart disease, stomach problems and issues with our immune system. We found that people with a temperament are more likely to have heart problems while those with a melancholic temperament are more likely to have problems with their immune system. The goal of this article is to help us understand how our temperament can affect our health and how we can prevent health problems
Gut Microbiota Alterations In Patients With Chronic Heart Failure And Chronic Kidney Disease
Chronic heart failure (CHF) and chronic kidney disease (CKD) are closely interconnected pathological conditions associated with high morbidity and mortality worldwide. Recent studies suggest that intestinal microbiota plays an important role in the progression of both cardiovascular and renal dysfunction through inflammatory, metabolic, and immune-mediated mechanisms. The aim of the present study was to investigate alterations of gut microbiota in patients with chronic heart failure and chronic kidney disease and to evaluate their association with clinical and metabolic disturbances
Airborne Droplet Infections: Whooping Cough (Pertussis) Pathogenesis
This article examines the pathogenesis of pertussis, which belongs to the group of airborne (droplet-transmitted) infectious diseases. The etiological agent of the disease, Bordetella pertussis, its biological characteristics, mechanisms of transmission, and routes of entry into the human body are described. In addition, the processes of pathogen adhesion to the respiratory epithelium, its proliferation, and its harmful effects on the body through toxin production are outlined
Airborne Infections, Whooping Cough, Bordetella Pertussis, Respiratory Tract Infections
Study of the Clinical Course of Myopathosis in Horses and the Effectiveness of Treatment
This scientific work studied the clinical course of myopathy in horses, pathological changes in the muscular system, and the effectiveness of treatment. The aim of the study was to determine clinical signs in horses affected with myopathy, evaluate functional disorders of the locomotor apparatus, and analyze the effectiveness of комплекс treatment methods. During the study, decreased muscle tone, muscle pain, impaired coordination of movement, lameness, swelling, and a tendency to muscle atrophy were observed. Increased body temperature, pulse, and respiratory rate were also recorded in diseased horses. As a result of treatment, clinical signs in the experimental group decreased significantly, and the functional condition of the muscles recovered in a shorter period. The obtained results indicate the importance of early diagnosis and complex treatment in reducing the severity of myopathy in horses.
Management of Obesity and Metabolic DysfunctionAssociated Steatohepatitis (MASH) in Multimorbid Patients
Metabolic dysfunction-associated steatohepatitis (MASH), formerly known as non-alcoholic steatohepatitis (NASH), represents the progressive inflammatory phenotype of metabolic dysfunction-associated steatotic liver disease (MASLD). The recent nomenclature shift from NAFLD/NASH to MASLD/MASH reflects a fundamental reconceptualization of this condition not merely as a hepatic disorder, but as a systemic manifestation of metabolic dysregulation
Metabolic dysfunction-associated steatohepatitis